Irreversible tyrosine kinase inhibitors induce the endocytosis and downregulation of ErbB2
Erb-b2 receptor tyrosine kinase 2 (ErbB2) is an oncogene that frequently overexpressed in a subset of cancers.Anti-ErbB2 therapies have been developed to treat these types of cancers.However, less is known Refrigeration Flaring Tool Kit about how anti-ErbB2 drugs affect the trafficking and degradation of ErbB2.We demonstrate that the reversible and